Adipose Triglyceride Lipase Deficiency Causes Tissue-specific Changes in Insulin Signaling
نویسندگان
چکیده
منابع مشابه
Adipose triglyceride lipase deficiency causes tissue-specific changes in insulin signaling.
Triacylglycerol accumulation in insulin target tissues is associated with insulin resistance. Paradoxically, mice with global targeted deletion of adipose triglyceride lipase (ATGL), the rate-limiting enzyme in triacylglycerol hydrolysis, display improved glucose tolerance and insulin sensitivity despite triacylglycerol accumulation in multiple tissues. To determine the molecular mechanisms for...
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STIMULATED INSULIN SECRETION Marie-Line Peyot, Claudiane Guay, Martin G. Latour, Julien Lamontagne, Roxane Lussier, Marco Pineda, Neil B. Ruderman, Guenter Haemmerle, Rudolf Zechner, Érik Joly, S. R. Murthy Madiraju, Vincent Poitout and Marc Prentki Molecular Nutrition Unit and the Montreal Diabetes Research Center, CRCHUM; Departments of Nutrition and Medicine, University of Montreal, Montreal...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2009
ISSN: 0021-9258
DOI: 10.1074/jbc.m109.047787